Thursday, March 28, 2019

Alzheimer’s disease, an eXtreme problem!

According to the amyloid's cascade hypothesis the wrong cut of the Ab protein and its aggregation into ordered fibrils is at the origin of the Alzheimer’s disease. Following this aggregation process with microscopic details is far to be possible experimentally. However, in silico modelling can help. Recently we have started working on a multi-scale simulation scheme to challenge the problem, and we could follow the aggregation of a simple but insightful amyloid peptide, the Ab(16-22), into prefibrillar states. You can enjoy the details here.  However, too much focus on the aggregation of Ab seems to be the wrong thing to do. In fact, it is a news of recent days that another potential drug intended to remove Ab plaques from the brain of Alzheimer's  affected patients just does not work, and the clinical trial was stopped, read more here. This news failure questions the amyloid cascade, or just indicates that when the symptoms are visible, treating Ab plaques is just to late, some interesting points are debated here.

13 comments:

  1. HOW I GOT CURED OF HERPES VIRUS.

    Hello everyone out there, i am here to give my testimony about a herbalist called dr imoloa. i was infected with herpes simplex virus 2 in 2013, i went to many hospitals for cure but there was no solution, so i was thinking on how i can get a solution out so that my body can be okay. one day i was in the pool side browsing and thinking of where i can get a solution. i go through many website were i saw so many testimonies about dr imoloa on how he cured them. i did not believe but i decided to give him a try, i contacted him and he prepared the herpes for me which i received through DHL courier service. i took it for two weeks after then he instructed me to go for check up, after the test i was confirmed herpes negative. am so free and happy. so, if you have problem or you are infected with any disease kindly contact him on email drimolaherbalmademedicine@gmail.com. or / whatssapp --+2347081986098.
    This testimony serve as an expression of my gratitude. he also have
    herbal cure for, FEVER, DIARRHOEA, MOUTH ULCER, MOUTH CANCER FATIGUE, MUSCLE ACHES, LUPUS, SKIN CANCER, PENILE CANCER, BREAST CANCER, PANCREATIC CANCER, CHRONIC KIDNEY DISEASE, VAGINAL CANCER, CERVICAL CANCER, DISEASE, JOINT PAIN, POLIO DISEASE, PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, CYSTIC FIBROSIS, SCHIZOPHRENIA, CORNEAL ULCER, EPILEPSY, FETAL ALCOHOL SPECTRUM, LICHEN PLANUS, COLD SORE, SHINGLES, CANCER, HEPATITIS A, B. DIABETES 1/2, HIV/AIDS, CHRONIC PANCERATIC, CHLAMYDIA, ZIKA VIRUS, EMPHYSEMA, LOW SPERM COUNT, ENZYMA, DRY COUGH, ARTHRITIS, LEUKAEMIA, LYME DISEASE, ASTHMA, IMPOTENCE, BARENESS/INFERTILITY, WEAK ERECTION, PENIS ENLARGEMENT. AND SO ON.

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    Replies
    1. I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain. During the first year, I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from Herpes Simplex Virus by this by Dr voodoo and she also gave the email address of this man and advise anyone to contact him for any kind of problem that he would be of help, so i wrote to Dr voodoo telling him about my (Herpes Virus) he told me not to worry that i was going to be cured!! Though i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr voodoo assured me, after some time i went to my doctor for test and it confirmed that i have be finally healed behold it was TRUE, So friends if anyone have such problem and need help contact Dr voodoo on his email: voodoospelltemple66@gmail.com Add Dr voodoo on whatsApp +2348140120719

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    2. ✅BINARY SCAM RECOVERY

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      ❌ You might have also come across some individuals that say they will give you guarantee on successful trades but they only end up as SCAMMERS as well. You here them say stuffs like 200% guaranteed in just 2 weeks and when you go into trade with them, they start telling you to pay profits percentage before you can get your income. These are all liars please avoid them. But if you have been a victim of this guys, then you should contact PYTHONAX now‼️

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    3. Am testifying of the miraculous work of a great traditional doctor called  Dr Shaibu Abacha. ..I have been suffering from herpes since last 2 years with my Husband but today I am happy that am cure from it with the herbal medicine made by  Dr Shaibu Abacha the great healer, I was browsing the Internet searching for help when I came across a testimony shared by someone on how  Dr Shaibu Abacha cure her from Herpes Disease. I quickly contacted him to get the cure and today i am now free from the Virus. Contact Dr Shaibu  Abacha for all kinds of ailment.
      Reach him on WhatsApp/call+2349051727475 or email drshaibuabacha@gmail.com. He also cure other sicknesses like:1} Staphylococcus2} Kidney problem3} Athsma4} Weak Erection5} Quick Ejaculation6} Body ODOUR7} Stroke8} Pile and many more.Please do not hide your sickness so your sickness will not hide you.

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  2. I want to use the means to thank Robinson.buckler for his good work I have been very sick with this horrible diseases for 9 months they all tell me there was no cure for me I have go to different hospital I always have same news, I was confused because I feel like ending my life that time thank God I was able to locate doctor Robinson.buckler who help me I found his email on site how people was writing Good about him I never believe he can really cured me until when I get my test done. I am so happy to tell you this Robinson.buckler have a herbal cure to Herpes and you can take the medicine according to his instruction you will found out that you will give testimony like me I take his herbal medicine for just 2 week. I am so happy today that I am really free from this sickness here is Robinson.buckler email Robinson.buckler (( @yahoo. com ))………………………………. you can reach him out now https://robinbuckler.com/

    ReplyDelete
  3. My Name is Faith, and am really grateful and thankful for what Dr voodoo
    has done for me and my family. I Was having HIV/AIDS for good three years
    with no solution, the diseases almost took my life and cause I was unable
    to work and I was also loosing lots of money for medication, but one
    faithful day when I went online, I met lots of testimonies about this great
    man so I decided to give it a try and to God be the glory he did it. he
    cured me of my diseases and am so happy and so pleased to Write about him
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    got mine, add Dr voodoo on whatsApp: +2348140120719 or just contact Dr
    voodoo via email, voodoospelltemple66@gmail.com

    ReplyDelete
  4. Am testifying of the miraculous work of a great traditional doctor called  Dr Shaibu Abacha. ..I have been suffering from herpes since last 2 years with my Husband but today I am happy that am cure from it with the herbal medicine made by  Dr Shaibu Abacha the great healer, I was browsing the Internet searching for help when I came across a testimony shared by someone on how  Dr Shaibu Abacha cure her from Herpes Disease. I quickly contacted him to get the cure and today i am now free from the Virus. Contact Dr Shaibu  Abacha for all kinds of ailment.
    Reach him on WhatsApp/call+2349051727475 or email drshaibuabacha@gmail.com. He also cure other sicknesses like:1} Staphylococcus2} Kidney problem3} Athsma4} Weak Erection5} Quick Ejaculation6} Body ODOUR7} Stroke8} Pile and many more.Please do not hide your sickness so your sickness will not hide you.

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  5. Herbal Penis Enlargement product is 100% guarantee to Enlarge and get a better ERECTION, the reason why most people are finding it difficult to enlarge Penis is that they believe on medical report, drugs and medical treatment which is not helpful for Penis Enlargement. Natural roots/herbs are the best remedies which can easily Enlarge your Penis permanently Contact Dr ODOMA via Email: drodomasolutionhome20@gmail.com or via WhatsApp: +2348100649947 for Natural root and herbal remedies put together to help you get Enlarge and Erect healthily. I also learn that Dr ODOMA also can cure other types of diseases like,HEPATITIS B,DIABETICS,CANCER,HPV,LOW SPERM CAM, HIV/STDS, FIBROSIS LOST OF WEIGHT, BREAST ENLARGEMENT, HIPS and BUMS ENLARGEMENT etc Thank you...........

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  6. Herbal Penis Enlargement product is 100% guarantee to Enlarge and get a better ERECTION, the reason why most people are finding it difficult to enlarge Penis is that they believe on medical report, drugs and medical treatment which is not helpful for Penis Enlargement. Natural roots/herbs are the best remedies which can easily Enlarge your Penis permanently Contact Dr ODOMA via Email: drodomasolutionhome20@gmail.com or via WhatsApp: +2348100649947 for Natural root and herbal remedies put together to help you get Enlarge and Erect healthily. I also learn that Dr ODOMA also can cure other types of diseases like,HEPATITIS B,DIABETICS,CANCER,HPV,LOW SPERM CAM, HIV/STDS, FIBROSIS LOST OF WEIGHT, BREAST ENLARGEMENT, HIPS and BUMS ENLARGEMENT etc Thank you...........

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  7. I am Leah Hart I live in Ohio USA I’m 32 Years old, am so happy I got my blank ATM card from united hacking company  blank ATM card that can withdraw $5,500 daily. I got it from him  last week and now I have withdrawn about $15,000 for free. The blank ATM withdraws money from any ATM machines and there is no name on it because it is blank just your PIN will be on it, it is not traceable and now I have money for business, shopping and enough money for me and my family to live on.I am really glad and happy i met united hacking company  because I met Five persons before him and they could not help me. But am happy now united hacking company  sent the card through DHL and I got it in two days. Get your own card from him right now, he is giving it out for small fee to help people even if it is illegal but it helps a lot and no one ever gets caught or traced. I’m happy and grateful to the united hacking company   because he changed my story all of a sudden. The card works in all countries that is the good news contact. email address: unitedblankatmhackcard@gmail.com 

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  8. I want to share this wonderful testimony to the Good people all over the world on how I was able to Enlarge my Penis by Dr.ODOMA I was living a shameful life from my young age, just last month as I was browsing on the internet about Penis size and Enlargement Products, I saw a testimony of a Man called George , testifying of how he was able to get his penis Enlarged by Dr.odoma and I decided to also Email Dr.odoma for my small penis size and he quickly respond to me and gave me the normal instructions which i did and then he shipped the product to me here in the united state which i received in just 3 working days and today i am very happy because i started seeing positive changes in my penis size in just 7 days of use. Dr.ODOMA herbal product is the best recommended for you and to whomever suffering from this shame or having any other diseases as well should Contact this great herbal doctor via his Email : drodomasolutionhome20@gmail.com and WhatsApp Him on +2348100649947

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  9. I want to share this wonderful testimony to the Good people all over the world on how I was able to Enlarge my Penis by Dr.ODOMA I was living a shameful life from my young age, just last month as I was browsing on the internet about Penis size and Enlargement Products, I saw a testimony of a Man called George , testifying of how he was able to get his penis Enlarged by Dr.odoma and I decided to also Email Dr.odoma for my small penis size and he quickly respond to me and gave me the normal instructions which i did and then he shipped the product to me here in the united state which i received in just 3 working days and today i am very happy because i started seeing positive changes in my penis size in just 7 days of use. Dr.ODOMA herbal product is the best recommended for you and to whomever suffering from this shame or having any other diseases as well should Contact this great herbal doctor via his Email : drodomasolutionhome20@gmail.com and WhatsApp Him on +2348100649947

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  10. Do you know that there is a great herbal doctor who can cure any deadly disease like herpes, hiv/aids, cancer, syphilis, madness, hepatitis b, STD e.t.c. well my main purpose of writing this to the whole world is about the great deeds DR ODOMA  did for me. I was diagnosed with a deadly disease called HIV/AIDS in 2006, ever since then I have been taking medications on till i met a great herbal doctor. Although I never believed in Herb medicine, I saw many testimonies on how he cured so many people and I decided to contact him. so i contacted him through his email, he gave me a form to fill, i filled it and sent it back to him and then he told me that he would require some items to prepare a herbal medicine for me. i didn't know where to find the items, and he told me that the only alternative is to help me get the items and he helped me purchase the items from the items seller. i promised myself to do anything to get cured, so i sent him the money and he prepared a medicine for me and he told me how i will be taking it. He asked me to have faith and believed in him which I did, 7 days later he asked me to go for a check-up, when I did the check-up I was tested for HIV Negative. All thanks to DR ODOMA. If you are passing through suffering and hardship and you need a way out , I advise you kindly contact him via his email on    drodomasolutionhome20@gmail.com  . You can also WhatsApp +2348100649947He is a specialist in all kinds of sickness and he can bring your EX back with his great spell.

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